New Multi-Targeted Antiproliferative Agents: Design and Synthesis of IC261-Based Oxindoles as Potential Tubulin, CK1 and EGFR Inhibitors

• Main Authors: Momen R. Fareed (Author), Mai E. Shoman (Author), Mohammed I. A. Hamed (Author), Mohamed Badr (Author), Hanin A. Bogari (Author), Sameh S. Elhady (Author), Tarek S. Ibrahim (Author), Gamal El-Din A (Author), Taha F. S. Ali (Author)
• Format: Book
• Published: MDPI AG, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A series of 3-benzylideneindolin-2-one compounds was designed and synthesized based on combretastatin A-4 and compound <b>IC261</b>, a dual casein kinase (CK1)/tubulin polymerization inhibitor, taking into consideration the pharmacophore required for EGFR-tyrosine kinase inhibition. The...