Astrocyte Elevated Gene-1 Mediates Glycolysis and Tumorigenesis in Colorectal Carcinoma Cells via AMPK Signaling

• Hoofdauteurs: Hong-tao Song (Auteur), Yu Qin (Auteur), Guo-dong Yao (Auteur), Zhen-nan Tian (Auteur), Song-bin Fu (Auteur), Jing-shu Geng (Auteur)
• Formaat: Boek
• Gepubliceerd in: Hindawi Limited, 2014-01-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

To investigate the role of AEG-1 in glycolysis and tumorigenesis, we construct myc-AEG-1 expression vector and demonstrate a novel mechanism that AEG-1 may increase the activity of AMPK by Thr172 phosphorylation. The higher expression levels of AEG-1 in colorectal carcinoma cells were found but show...