Novel <it>APC </it>mutations in Czech and Slovak FAP families: clinical and genetic aspects

• Main Authors: Vesela Kamila (Author), Ilencikova Denisa (Author), Kotlas Jaroslav (Author), Zidkova Katerina (Author), Kebrdlova Vera (Author), Sulova Martina (Author), Stekrova Jitka (Author), Kohoutova Milada (Author)
• Format: Book
• Published: BMC, 2007-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Germline mutations in the adenomatous polyposis gene (<it>APC</it>) result in familial adenomatous polyposis (FAP). FAP is an autosomal dominantly inherited disorder predisposing to colorectal cancer. Typical FAP is chara...