Inhibition of PDE‐4 isoenzyme attenuates frequency and overall contractility of agonist‐evoked ureteral phasic contractions

• Главные авторы: Iris Lim (Автор), Taishi Masutani (Автор), Hikaru Hashitani (Автор), Russ Chess‐Williams (Автор), Donna Sellers (Автор)
• Формат: ‌
• Опубликовано: Wiley, 2024-02-01T00:00:00Z.
• Предметы: article
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Abstract The aim of this study was to investigate the functional role of phosphodiesterase enzymes (PDE) in the isolated porcine ureter. Distal ureteral strips were mounted in organ baths and pre‐contracted with 5‐HT (100 μM). Upon generation of stable phasic contractions, PDE‐4 and PDE‐5 inhibitors...