Dissolution of an ensemble of differently shaped poly-dispersed drug particles undergoing solubility reduction: mathematical modelling

• Main Authors: Michela Abrami (Author), Lucia Grassi (Author), Rosario Di Vittorio (Author), Dritan Hasa (Author), Beatrice Perissutti (Author), Dario Voinovich (Author), Gabriele Grassi (Author), Italo Colombo (Author), Mario Grassi (Author)
• Format: Book
• Published: International Association of Physical Chemists (IAPC), 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The aim of this theoretical paper is to develop a mathematical model for describing the dissolution process, in a finite liquid environment, of an ensemble of poly-dispersed drug particles, in form of sphere, cylinder and parallelepiped that can undergo solubility reduction due to phase transition i...