Broadening sarbecovirus neutralization with bispecific antibodies combining distinct conserved targets on the receptor binding domain

• Main Authors: Denise Guerra (Author), Laura Radić (Author), Mitch Brinkkemper (Author), Meliawati Poniman (Author), Lara van der Maas (Author), Jonathan L. Torres (Author), Andrew B. Ward (Author), Kwinten Sliepen (Author), Janke Schinkel (Author), Rogier W. Sanders (Author), Marit J. van Gils (Author), Tim Beaumont (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Monoclonal neutralizing antibodies (mAbs) are considered an important prophylactic against SARS-CoV-2 infection in at-risk populations and a strategy to counteract future sarbecovirus-induced disease. However, most mAbs isolated so far neutralize only a few sarbecovirus strains. Therefore, there is...