Genomics-driven derivatization of the bioactive fungal sesterterpenoid variecolin: Creation of an unnatural analogue with improved anticancer properties

• Main Authors: Dexiu Yan (Author), Jemma Arakelyan (Author), Teng Wan (Author), Ritvik Raina (Author), Tsz Ki Chan (Author), Dohyun Ahn (Author), Vladimir Kushnarev (Author), Tsz Kiu Cheung (Author), Ho Ching Chan (Author), Inseo Choi (Author), Pui Yi Ho (Author), Feijun Hu (Author), Yujeong Kim (Author), Hill Lam Lau (Author), Ying Lo Law (Author), Chi Seng Leung (Author), Chun Yin Tong (Author), Kai Kap Wong (Author), Wing Lam Yim (Author), Nikolay S. Karnaukhov (Author), Richard Y.C. Kong (Author), Maria V. Babak (Author), Yudai Matsuda (Author)
• Format: Book
• Published: Elsevier, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A biosynthetic gene cluster for the bioactive fungal sesterterpenoids variecolin (1) and variecolactone (2) was identified in Aspergillus aculeatus ATCC 16872. Heterologous production of 1 and 2 was achieved in Aspergillus oryzae by expressing the sesterterpene synthase VrcA and the cytochrome P450...