Chymase inhibitor prevents the development and progression of non-alcoholic steatohepatitis in rats fed a high-fat and high-cholesterol diet

• Main Authors: Yuta Miyaoka (Author), Denan Jin (Author), Keitaro Tashiro (Author), Koji Komeda (Author), Shinsuke Masubuchi (Author), Fumitoshi Hirokawa (Author), Michihiro Hayashi (Author), Shinji Takai (Author), Kazuhisa Uchiyama (Author)
• Format: Book
• Published: Elsevier, 2017-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The effect of the chymase inhibitor TY-51469 on the development and progression of non-alcoholic steatohepatitis (NASH) was evaluated in rats fed a high-fat and high-cholesterol (HFC) diet. To evaluate the preventive effect of TY-51469 on the development of NASH, stroke-prone spontaneously hypertens...