The humanized DRAGA mouse (HLA-A2. HLA-DR4. RAG1 KO. IL-2R g c KO. NOD) establishes inducible and transmissible models for influenza type A infections

• Main Authors: Mirian Mendoza (Author), Devi Gunasekera (Author), Kathleen P. Pratt (Author), Qi Qiu (Author), Sofia Casares (Author), Teodor-D. Brumeanu (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We have engineered a Human Immune System (HIS)-reconstituted mouse strain (DRAGA mouse: HLA-A2. HLA-DR4. Rag1 KO. IL-2Rγc KO. NOD) in which the murine immune system has been replaced by a long-term, functional HIS via infusion of CD34+ hematopoietic stem cells (HSC) from cord blood. Herein, we repor...