A Matrine Derivative M54 Suppresses Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Loss by Targeting Ribosomal Protein S5

• Main Authors: Zhi Xin (Author), Cui Jin (Author), Liu Chao (Author), Zhang Zheng (Author), Cao Liehu (Author), Pan Panpan (Author), Weng Weizong (Author), Zhai Xiao (Author), Zhao Qingjie (Author), Hu Honggang (Author), Qin Longjuan (Author), Chen Xiao (Author), Su Jiacan (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Post-menopausal osteoporosis (PMOP) is a metabolic bone disorder characterized by low bone mass and micro-architectural deterioration of bone tissue. The over-activated osteoclastogenesis, which plays an important role in osteoporosis, has become an important therapeutic target. M54 was a bioactive...