HMGB1 and Histones Play a Significant Role in Inducing Systemic Inflammation and Multiple Organ Dysfunctions in Severe Acute Pancreatitis

• المؤلفون الرئيسيون: Runkuan Yang (مؤلف), Jyrki Tenhunen (مؤلف), Tor Inge Tonnessen (مؤلف)
• التنسيق: كتاب
• منشور في: Hindawi Limited, 2017-01-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Severe acute pancreatitis (SAP) starts as a local inflammation of pancreatic tissue that induces the development of multiple extrapancreatic organs dysfunction; however, the underlying mechanisms are still not clear. Ischemia-reperfusion, circulating inflammatory cytokines, and possible bile cytokin...