Restoring Ureagenesis in Hepatocytes by CRISPR/Cas9-mediated Genomic Addition to Arginase-deficient Induced Pluripotent Stem Cells
Urea cycle disorders are incurable enzymopathies that affect nitrogen metabolism and typically lead to hyperammonemia. Arginase deficiency results from a mutation in Arg1, the enzyme regulating the final step of ureagenesis and typically results in developmental disabilities, seizures, spastic diple...
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Asıl Yazarlar: | , , , , , , , , , , , , , , |
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Materyal Türü: | Kitap |
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Elsevier,
2016-01-01T00:00:00Z.
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A1234.567 |
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Kopya Bilgisi 1 | Kütüphanede |