Subcutaneous preconditioning increases invasion and metastatic dissemination in mouse colorectal cancer models

• Main Authors: Patricia Alamo (Author), Alberto Gallardo (Author), Miguel A. Pavón (Author), Isolda Casanova (Author), Manuel Trias (Author), Maria A. Mangues (Author), Esther Vázquez (Author), Antonio Villaverde (Author), Ramon Mangues (Author), Maria V. Céspedes (Author)
• Format: Book
• Published: The Company of Biologists, 2014-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mouse colorectal cancer (CRC) models generated by orthotopic microinjection of human CRC cell lines reproduce the pattern of lymphatic, haematological and transcoelomic spread but generate low metastatic efficiency. Our aim was to develop a new strategy that could increase the metastatic efficiency...