P-glycoprotein Mediated Efflux Limits Substrate and Drug Uptake in a Preclinical Brain Metastases of Breast Cancer Model

• Автори: Chris E Adkins (Автор), Rajendar Kumar Mittapalli (Автор), Vamshi Krishna Manda (Автор), Mohamed Ismail Nounou (Автор), Afroz Shareef Mohammad (Автор), Tori Breanne Terrrell (Автор), Kaci Ann Bohn (Автор), Celik eYasemin (Автор), Tiffany Renee Grothe (Автор), Julie Ann Lockman (Автор), Paul Richard Lockman (Автор)
• Формат: Книга
• Опубліковано: Frontiers Media S.A., 2013-11-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

The blood-brain barrier (BBB) is a specialized vascular interface that restricts the entry of many compounds into brain. This is accomplished through the sealing of vascular endothelial cells together with tight junction proteins to prevent paracellular diffusion. In addition, the BBB has a high deg...