Novel Two-Step Classifier for Torsades de Pointes Risk Stratification from Direct Features

• Váldodahkkit: Jaimit Parikh (Dahkki), Viatcheslav Gurev (Dahkki), John J. Rice (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Frontiers Media S.A., 2017-11-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

While pre-clinical Torsades de Pointes (TdP) risk classifiers had initially been based on drug-induced block of hERG potassium channels, it is now well established that improved risk prediction can be achieved by considering block of non-hERG ion channels. The current multi-channel TdP classifiers c...