Possible Involvement of Small Oligomers of Amyloid-β Peptides in 15-Deoxy-Δ 12,14 Prostaglandin J2-Sensitive Microglial Activation

• Main Authors: Kazuyuki Takata (Author), Yoshihisa Kitamura (Author), Masaaki Umeki (Author), Daiju Tsuchiya (Author), Jun-ichi Kakimura (Author), Takashi Taniguchi (Author), Peter J. Gebicke-Haerter (Author), Shun Shimohama (Author)
• Format: Book
• Published: Elsevier, 2003-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In Alzheimer's disease, fibrillar amyloid-β (Aβ) peptides form senile plaques associated with microglia. However, the relationship between Aβ peptides and microglia is not fully understood. In this study, the incubation of Aβ1-40 (Aβ40) produced small oligomers, while incubation with Aβ1-42 (Aβ...