1D NMR WaterLOGSY as an efficient method for fragment-based lead discovery

• Үндсэн зохиолчид: Claire Raingeval (Зохиогч), Olivier Cala (Зохиогч), Béatrice Brion (Зохиогч), Marc Le Borgne (Зохиогч), Roderick Eliot Hubbard (Зохиогч), Isabelle Krimm (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

WaterLOGSY is a sensitive ligand-observed NMR experiment for detection of interaction between a ligand and a protein and is now well-established as a screening technique for fragment-based lead discovery. Here we develop and assess a protocol to derive ligand epitope mapping from WaterLOGSY data and...