DDIT4/mTOR signaling pathway mediates cantharidin-induced hepatotoxicity and cellular damage

• Main Authors: Wenchao Tang (Author), Yue Pan (Author), Can Zhu (Author), Didong Lou (Author), Fang Peng (Author), Qin Shi (Author), Yuanyuan Xiao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BackgroundCantharidin (CTD) extracted from the traditional Chinese medicine Mylabris has significant therapeutic effects on various tumors. However, the high toxicity of CTD can cause serious liver damage, although the related molecular mechanisms remain unclear.MethodsIn this study, we established...