Pharmacokinetics of isoniazid in Wistar rats exposed to ethanol

• Main Authors: Taísa Busaranho Franchin (Author), Jonata Augusto de Oliveira (Author), Caroline Damico Candido (Author), Evelin dos Santos Martins (Author), Elias Carvalho Padilha (Author), Michel Leandro de Campos (Author), Rosângela Gonçalves Peccinini (Author)
• Format: Book
• Published: Universidade de São Paulo, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Tuberculosis treatment consists of a drug combination, where isoniazid is the core drug and alcoholism is a factor highly related to poor patient compliance with the therapy. CYP2E1 is an enzyme involved both in the metabolism of ethanol and in the formation of hepatotoxic compounds during...