Environmental factors regulate Paneth cell phenotype and host susceptibility to intestinal inflammation in Irgm1-deficient mice

• Main Authors: Allison R. Rogala (Author), Alexi A. Schoenborn (Author), Brian E. Fee (Author), Viviana A. Cantillana (Author), Maria J. Joyce (Author), Raad Z. Gharaibeh (Author), Sayanty Roy (Author), Anthony A. Fodor (Author), R. Balfour Sartor (Author), Gregory A. Taylor (Author), Ajay S. Gulati (Author)
• Format: Book
• Published: The Company of Biologists, 2018-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Crohn's disease (CD) represents a chronic inflammatory disorder of the intestinal tract. Several susceptibility genes have been linked to CD, though their precise role in the pathogenesis of this disorder remains unclear. Immunity-related GTPase M (IRGM) is an established risk allele in CD. We...