Preparation of Solid Dispersions of Simvastatin and Soluplus Using a Single-Step Organic Solvent-Free Supercritical Fluid Process for the Drug Solubility and Dissolution Rate Enhancement

• Main Authors: Uttom Nandi (Author), Adejumoke Lara Ajiboye (Author), Preksha Patel (Author), Dennis Douroumis (Author), Vivek Trivedi (Author)
• Format: Book
• Published: MDPI AG, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The study was designed to investigate the feasibility of supercritical carbon dioxide (scCO₂) processing for the preparation of simvastatin (SIM) solid dispersions (SDs) in Soluplus^® (SOL) at temperatures below polymer's glass transition. The SIM co...