Aloe-Emodin Induces Mitochondrial Dysfunction and Pyroptosis by Activation of the Caspase-9/3/Gasdermin E Axis in HeLa Cells

• Main Authors: Tonghui Li (Author), Liuliu Shi (Author), Wenqiang Liu (Author), Xuhao Hu (Author), Yuanjian Hui (Author), Maojun Di (Author), Shen Xue (Author), Yan Zheng (Author), Mengjuan Yao (Author), Chen Li (Author), Kun Meng (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aloe-emodin (1,8-dihydroxy-3-hydroxymethyl-anthraquinone), derived from some Chinese edible medicinal herbs, exerts a potential anticancer activity on various cancer cells, making it a drug candidate for cancer therapy. Yet, the role of aloe-emodin in pyroptosis, a new type of cell death, is unchara...