Hollow copper sulfide nanoparticles carrying ISRIB for the sensitized photothermal therapy of breast cancer and brain metastases through inhibiting stress granule formation and reprogramming tumor‐associated macrophages

• Main Authors: Fan Tong (Author), Haili Hu (Author), Yanyan Xu (Author), Yang Zhou (Author), Rou Xie (Author), Ting Lei (Author), Yufan Du (Author), Wenqin Yang (Author), Siqin He (Author), Yuan Huang (Author), Tao Gong (Author), Huile Gao (Author)
• Format: Book
• Published: Elsevier, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

As known, the benefits of photothermal therapy (PTT) are greatly limited by the heat tolerance of cancer cells resulting from overexpressed heat shock proteins (HSPs). Then HSPs further trigger the formation of stress granules (SGs) that regulate protein expression and cell viability under various s...