Tryptophan Challenge in Healthy Controls and People with Schizophrenia: Acute Effects on Plasma Levels of Kynurenine, Kynurenic Acid and 5-Hydroxyindoleacetic Acid

• Main Authors: Korrapati V. Sathyasaikumar (Author), Francesca M. Notarangelo (Author), Deanna L. Kelly (Author), Laura M. Rowland (Author), Stephanie M. Hare (Author), Shuo Chen (Author), Chen Mo (Author), Robert W. Buchanan (Author), Robert Schwarcz (Author)
• Format: Book
• Published: MDPI AG, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The pivotal tryptophan (TRP) metabolite kynurenine is converted to several neuroactive compounds, including kynurenic acid (KYNA), which is elevated in the brain and cerebrospinal fluid of people with schizophrenia (SZ) and may contribute to cognitive abnormalities in patients. A small proportion of...