3-aryl-4-(3,4,5-trimethoxyphenyl)pyridines inhibit tubulin polymerisation and act as anticancer agents

• Egile Nagusiak: Chao Wang (Egilea), Yujing Zhang (Egilea), Shanbo Yang (Egilea), Lingyu Shi (Egilea), Yutao Xiu (Egilea), Yudong Wu (Egilea), Hongfei Jiang (Egilea)
• Formatua: Liburua
• Argitaratua: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

AbstractA series of cis-restricted 3-aryl-4-(3,4,5-trimethoxyphenyl)pyridines as novel tubulin polymerisation inhibitors was designed based on molecular docking. Compound 9p, exhibited potent antiproliferative activity against HeLa, MCF-7, and A549 cell lines. Mechanism studies indicated that 9p pot...