Discovery of Potent Dual EGFR/HER2 Inhibitors Based on Thiophene Scaffold Targeting H1299 Lung Cancer Cell Line

• Main Authors: Ranza Elrayess (Author), Yasmine M. Abdel Aziz (Author), Mohamed Saleh Elgawish (Author), Marwa Elewa (Author), Asmaa S. A. Yassen (Author), Sameh S. Elhady (Author), Hosam A. Elshihawy (Author), Mohamed M. Said (Author)
• Format: Book
• Published: MDPI AG, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dual targeting of epidermal growth factor receptor (EGFR) and human EGFR-related receptor 2 (HER2) is a proven approach for the treatment of lung cancer. With the aim of discovering effective dual EGFR/HER2 inhibitors targeting non-small cell lung cancer cell line H1299, three series of thieno[2,3-d...