Protective Effects of Kakkalide From Flos Puerariae on Ethanol-Induced Lethality and Hepatic Injury Are Dependent on Its Biotransformation by Human Intestinal Microflora
ABSTRACT: When kakkalide, which was isolated from Flos Puerariae, was incubated with human fecal bacteria, kakkalide was metabolized to irisolidone via kakkalidone. When kakkalide (250 mg/kg) was orally administered to rats, irisolidone, but not kakkalide, was detected in the blood. The mortality as...
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Elsevier,
2003-01-01T00:00:00Z.
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A1234.567 |
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