Protective Effects of Kakkalide From Flos Puerariae on Ethanol-Induced Lethality and Hepatic Injury Are Dependent on Its Biotransformation by Human Intestinal Microflora

• Päätekijät: Yeo-Ok Han (Tekijä), Myung Joo Han (Tekijä), Sung-Hwan Park (Tekijä), Dong-Hyun Kim (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Elsevier, 2003-01-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

ABSTRACT: When kakkalide, which was isolated from Flos Puerariae, was incubated with human fecal bacteria, kakkalide was metabolized to irisolidone via kakkalidone. When kakkalide (250 mg/kg) was orally administered to rats, irisolidone, but not kakkalide, was detected in the blood. The mortality as...