Identification of Heme Oxygenase-1 as a Putative DNA-Binding Protein

• Main Authors: Alejandro Scaffa (Author), George A. Tollefson (Author), Hongwei Yao (Author), Salu Rizal (Author), Joselynn Wallace (Author), Nathalie Oulhen (Author), Jennifer F. Carr (Author), Katy Hegarty (Author), Alper Uzun (Author), Phyllis A. Dennery (Author)
• Format: Book
• Published: MDPI AG, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Heme oxygenase-1 (HO-1) is a rate-limiting enzyme in degrading heme into biliverdin and iron. HO-1 can also enter the nucleus and regulate gene transcription independent of its enzymatic activity. Whether HO-1 can alter gene expression through direct binding to target DNA remains unclear. Here, we p...