Probing the DNA Reactivity and the Anticancer Properties of a Novel Tubercidin-Pt(II) Complex

• Main Authors: Stefano D'Errico (Author), Andrea Patrizia Falanga (Author), Domenica Capasso (Author), Sonia Di Gaetano (Author), Maria Marzano (Author), Monica Terracciano (Author), Giovanni Nicola Roviello (Author), Gennaro Piccialli (Author), Giorgia Oliviero (Author), Nicola Borbone (Author)
• Format: Book
• Published: MDPI AG, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Herein, we reported on the synthesis of a novel Pt(II) neutral complex having as ligand the nucleoside tubercidin, a potent anti-tumor agent extracted from the bacterium <i>Streptomyces Tubercidicus</i>. In detail, the chelation of the metal by a diamine linker installed at C6 purine pos...