Probing the DNA Reactivity and the Anticancer Properties of a Novel Tubercidin-Pt(II) Complex

• Үндсэн зохиолчид: Stefano D'Errico (Зохиогч), Andrea Patrizia Falanga (Зохиогч), Domenica Capasso (Зохиогч), Sonia Di Gaetano (Зохиогч), Maria Marzano (Зохиогч), Monica Terracciano (Зохиогч), Giovanni Nicola Roviello (Зохиогч), Gennaro Piccialli (Зохиогч), Giorgia Oliviero (Зохиогч), Nicola Borbone (Зохиогч)
• Формат: Ном
• Хэвлэсэн: MDPI AG, 2020-07-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Herein, we reported on the synthesis of a novel Pt(II) neutral complex having as ligand the nucleoside tubercidin, a potent anti-tumor agent extracted from the bacterium <i>Streptomyces Tubercidicus</i>. In detail, the chelation of the metal by a diamine linker installed at C6 purine pos...