Comparison of Two Transmission Electron Microscopy Methods to Visualize Drug-Induced Alterations of Gram-Negative Bacterial Morphology

• Main Authors: Hang Thi Nguyen (Author), Lisa A. O'Donovan (Author), Henrietta Venter (Author), Cecilia C. Russell (Author), Adam McCluskey (Author), Stephen W. Page (Author), Darren J. Trott (Author), Abiodun D. Ogunniyi (Author)
• Format: Book
• Published: MDPI AG, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this study, we optimized and compared different transmission electron microscopy (TEM) methods to visualize changes to Gram-negative bacterial morphology induced by treatment with a robenidine analogue (NCL195) and colistin combination. Aldehyde-fixed bacterial cells (untreated, treated with coli...