Comparative Pharmacokinetics and Local Tolerance of Tenofovir Alafenamide (TAF) From Subcutaneous Implant in Rabbits, Dogs, and Macaques

Comparative Pharmacokinetics and Local Tolerance of Tenofovir Alafenamide (TAF) From Subcutaneous Implant in Rabbits, Dogs, and Macaques

The administration of antiretrovirals (ARVs) for HIV pre-exposure prophylaxis (PrEP) is highly efficacious and may benefit from new long-acting (LA) drug delivery approaches. This paper describes a subcutaneous, reservoir-style implant for the LA delivery of tenofovir alafenamide (TAF) and documents...

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Main Authors: G. J. Gatto (Author), A. Krovi (Author), L. Li (Author), I. Massud (Author), A. Holder (Author), J. Gary (Author), P. Mills (Author), J. Mitchell (Author), E. Luecke (Author), Z. R. Demkovich (Author), W. Heneine (Author), J. G. García-Lerma (Author), M. A. Marzinke (Author), R. M. Brand (Author), C. W. Dobard (Author), L. M. Johnson (Author), A. Van Der Straten (Author)
Format: Book
Published: Frontiers Media S.A., 2022-07-01T00:00:00Z.
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