Co-Amorphous Formation of Simvastatin-Ezetimibe: Enhanced Physical Stability, Bioavailability and Cholesterol-Lowering Effects in LDLr−/−Mice

• Main Authors: Shamuha Bahetibieke (Author), Sakib M. Moinuddin (Author), Asiya Baiyisaiti (Author), Xiaoang Liu (Author), Jie Zhang (Author), Guomin Liu (Author), Qin Shi (Author), Ankang Peng (Author), Jun Tao (Author), Chang Di (Author), Ting Cai (Author), Rong Qi (Author)
• Format: Book
• Published: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hypercholesterolemia is one of the independent risk factors for the development of cardiovascular diseases such as atherosclerosis. The treatment of hypercholesterolemia is of great significance to reduce clinical cardiovascular events and patient mortality. Simvastatin (SIM) and ezetimibe (EZE) are...