A U1i RNA that Enhances HIV-1 RNA Splicing with an Elongated Recognition Domain Is an Optimal Candidate for Combination HIV-1 Gene Therapy

• Autori principali: Olivier Del Corpo (Autore), Ryan P. Goguen (Autore), Camille M.G. Malard (Autore), Aïcha Daher (Autore), Susan Colby-Germinario (Autore), Robert J. Scarborough (Autore), Anne Gatignol (Autore)
• Natura: Libro
• Pubblicazione: Elsevier, 2019-12-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

U1 interference (U1i) RNAs can be designed to correct splicing defects and target pathogenic RNA, such as HIV-1 RNA. In this study, we show that U1i RNAs that enhance HIV-1 RNA splicing are more effective at inhibiting HIV-1 production compared to top U1i RNAs that inhibit polyadenylation of HIV-1 R...