Continuous Infusion of High Doses of Cefepime in Intensive Care Unit: Assessment of Steady-State Plasma Level and Incidence on Neurotoxicity

• Main Authors: Vanessa Jean-Michel (Author), Corentin Homey (Author), Patrick Devos (Author), Pierre-Yves Delannoy (Author), Nicolas Boussekey (Author), Thomas Caulier (Author), Olivier Leroy (Author), Hugues Georges (Author)
• Format: Book
• Published: MDPI AG, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Continuous infusion (CI) with high doses of cefepime is recommended in the empirical antimicrobial regimen of critically ill patients with suspected Gram-negative sepsis. This study aimed to determine factors associated with cefepime overdosing and the incidence of cefepime-induced neurotoxicity (CI...