CRISPR-Cas13a Inhibits HIV-1 Infection

• Main Authors: Lijuan Yin (Author), Fei Zhao (Author), Hong Sun (Author), Zhen Wang (Author), Yu Huang (Author), Weijun Zhu (Author), Fengwen Xu (Author), Shan Mei (Author), Xiaoman Liu (Author), Di Zhang (Author), Liang Wei (Author), Shan Cen (Author), Siqi Hu (Author), Chen Liang (Author), Fei Guo (Author)
• Format: Book
• Published: Elsevier, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

CRISPR-Cas provides bacteria and archaea with immunity against invading phages and foreign plasmid DNA and has been successfully adapted for gene editing in a variety of species. The class 2 type VI CRISPR-Cas effector Cas13a targets and cleaves RNA, providing protection against RNA phages. Here we...