Factor-Reduced Human Induced Pluripotent Stem Cells Efficiently Differentiate into Neurons Independent of the Number of Reprogramming Factors

• Prif Awduron: Andreas Hermann (Awdur), Jeong Beom Kim (Awdur), Sumitra Srimasorn (Awdur), Holm Zaehres (Awdur), Peter Reinhardt (Awdur), Hans R. Schöler (Awdur), Alexander Storch (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Hindawi Limited, 2016-01-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) by overexpression of the transcription factors OCT4, SOX2, KLF4, and c-Myc holds great promise for the development of personalized cell replacement therapies. In an attempt to minimize the risk of chromosomal disruption and t...