TNF-α Downregulation Modifies Insulin Receptor Substrate 1 (IRS-1) in Metabolic Signaling of Diabetic Insulin-Resistant Hepatocytes

• Päätekijät: Iraj Alipourfard (Tekijä), Nelly Datukishvili (Tekijä), Davit Mikeladze (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Hindawi Limited, 2019-01-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

One of the major mechanisms of hyperglycemia in type 2 diabetes is insulin resistance (IR) which can induce free fatty acids like palmitate. In hepatic cell, as an insulin target tissue, insulin resistance can be stimulated by inflammatory cytokine TNF-α. The interaction of intracellular TNF-α signa...