TNF-α Downregulation Modifies Insulin Receptor Substrate 1 (IRS-1) in Metabolic Signaling of Diabetic Insulin-Resistant Hepatocytes

• Principais autores: Iraj Alipourfard (Autor), Nelly Datukishvili (Autor), Davit Mikeladze (Autor)
• Formato: Livro
• Publicado em: Hindawi Limited, 2019-01-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

One of the major mechanisms of hyperglycemia in type 2 diabetes is insulin resistance (IR) which can induce free fatty acids like palmitate. In hepatic cell, as an insulin target tissue, insulin resistance can be stimulated by inflammatory cytokine TNF-α. The interaction of intracellular TNF-α signa...