Strong and long-lasting antinociceptive and anti-inflammatory conjugate of naturally occurring oleanolic acid and aspirin

• Main Authors: Barbara Bednarczyk-Cwynar (Author), Natalia Wachowiak (Author), Michal Szulc (Author), Ewa Kaminska (Author), Anna Bogacz (Author), Joanna Bartkowiak-Wieczorek (Author), Lucjusz Zaprutko (Author), Przemyslaw Lukasz Mikolajczak (Author)
• Format: Book
• Published: Frontiers Media S.A., 2016-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The conjugate 8 was obtained as a result of condensation of 3-hydroxyiminooleanolic acid morfolide (7) and aspirin in dioxane. Analgesic effect of OAO-ASA (8) for the range of doses 0.3 - 300.0 mg/kg (p.o.) was performed in mice using a hot plate test. Anti-inflammatory activity was assessed on carr...