NLRP1 Functions Downstream of the MAPK/ERK Signaling via ATF4 and Contributes to Acquired Targeted Therapy Resistance in Human Metastatic Melanoma

• Главные авторы: Zili Zhai (Автор), Prasanna K. Vaddi (Автор), Jenny Mae Samson (Автор), Tomoya Takegami (Автор), Mayumi Fujita (Автор)
• Формат: ‌
• Опубликовано: MDPI AG, 2020-12-01T00:00:00Z.
• Предметы: article
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The <i>BRAF</i> V600E mutation leads to constitutive activation of the mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) pathway and its downstream effector responses. Uncovering the hidden downstream effectors can aid in understanding melanoma biology a...