Growth Arrest-Specific 6 Enhances the Suppressive Function of CD4+CD25+ Regulatory T Cells Mainly through Axl Receptor

• Main Authors: Guang-ju Zhao (Author), Jia-yi Zheng (Author), Jia-lan Bian (Author), Long-wang Chen (Author), Ning Dong (Author), Yan Yu (Author), Guang-liang Hong (Author), Arvine Chandoo (Author), Yong-Ming Yao (Author), Zhong-qiu Lu (Author)
• Format: Book
• Published: Hindawi Limited, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background. Growth arrest-specific (Gas) 6 is one of the endogenous ligands of TAM receptors (Tyro3, Axl, and Mertk), and its role as an immune modulator has been recently emphasized. Naturally occurring CD4+CD25+ regulatory T cells (Tregs) are essential for the active suppression of autoimmunity. T...