Polo-like kinase 4 as a potential predictive biomarker of chemoradioresistance in locally advanced rectal cancer

• Main Authors: Hyunseung Oh (Author), Soon Gu Kim (Author), Sung Uk Bae (Author), Sang Jun Byun (Author), Shin Kim (Author), Jae-Ho Lee (Author), Ilseon Hwang (Author), Sun Young Kwon (Author), Hye Won Lee (Author)
• Format: Book
• Published: Korean Society of Pathologists & the Korean Society for Cytopathology, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background Polo-like kinase 4 (PLK4) is a serine/threonine protein kinase located in the centriole of the chromosome during the cell cycle. PLK4 overexpression has been described in a variety of many common human epithelial tumors. Conversely, PLK4 acts as a haploinsufficient tumor suppressor in som...