Rabphilin-3A as a novel target to reverse α-synuclein-induced synaptic loss in Parkinson's disease

• Main Authors: Elena Ferrari (Author), Diego Scheggia (Author), Elisa Zianni (Author), Maria Italia (Author), Marta Brumana (Author), Luca Palazzolo (Author), Chiara Parravicini (Author), Andrea Pilotto (Author), Alessandro Padovani (Author), Elena Marcello (Author), Ivano Eberini (Author), Paolo Calabresi (Author), Monica Diluca (Author), Fabrizio Gardoni (Author)
• Format: Book
• Published: Elsevier, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Toxic aggregates of α-synuclein (αsyn) are considered key drivers of Parkinson's disease (PD) pathology. In early PD, αsyn induces synaptic dysfunction also modulating the glutamatergic neurotransmission. However, a more detailed understanding of the molecular mechanisms underlying αsyn-trigger...