A mouse pancreatic organoid model to compare PD-L1 blocking antibodies

• Main Authors: Guangyuan Li (Author), Susmita Ghosh (Author), JuMe Park (Author), Hyunsu Shin (Author), Mamatha Garige (Author), Gregory Reaman (Author), Carole Sourbier (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Immune checkpoint inhibitors (ICIs) have changed the therapeutic landscape for cancer patients, but diabetes, a rare, severe immune-related endocrinopathy, is linked to ICI therapy. It is unclear whether glycosylation of ICIs may play a role in the development of this adverse event and how the physi...