miR-200c Prevents TGF-β1-Induced Epithelial-to-Mesenchymal Transition and Fibrogenesis in Mesothelial Cells by Targeting ZEB2 and Notch1

• Main Authors: Jessica Y.S. Chu (Author), Mel K.M. Chau (Author), Caleb C.Y. Chan (Author), Andrew C.P. Tai (Author), Kwok Fan Cheung (Author), Tak Mao Chan (Author), Susan Yung (Author)
• Format: Book
• Published: Elsevier, 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Peritoneal fibrosis and loss of transport function is a common complication contributing to adverse outcomes in patients on long-term peritoneal dialysis (PD). Epithelial-to-mesenchymal transition (EMT) in mesothelial cells is a salient feature, but its triggering mechanisms remain obscure. Dysregul...