Inhibition of alpha-synuclein seeded fibril formation and toxicity by herbal medicinal extracts

• Main Authors: Mustafa T. Ardah (Author), Simona S. Ghanem (Author), Sara A. Abdulla (Author), Guohua Lv (Author), Mohamed M. Emara (Author), Katerina E. Paleologou (Author), Nishant N. Vaikath (Author), Jia-Hong Lu (Author), Min Li (Author), Konstantinos Vekrellis (Author), David Eliezer (Author), Omar M. A. El-Agnaf (Author)
• Format: Bog
• Udgivet: BMC, 2020-03-01T00:00:00Z.
• Fag: article
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Abstract Background Recent studies indicated that seeded fibril formation and toxicity of α-synuclein (α-syn) play a main role in the pathogenesis of certain diseases including Parkinson's disease (PD), multiple system atrophy, and dementia with Lewy bodies. Therefore, examination of compounds...