Allosteric inhibition of carnosinase (CN1) by inducing a conformational shift

• Main Authors: Verena Peters (Author), Claus P. Schmitt (Author), Tim Weigand (Author), Kristina Klingbeil (Author), Christian Thiel (Author), Antje van den Berg (Author), Vittorio Calabrese (Author), Peter Nawroth (Author), Thomas Fleming (Author), Elisabete Forsberg (Author), Andreas H. Wagner (Author), Markus Hecker (Author), Giulio Vistoli (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In humans, low serum carnosinase (CN1) activity protects patients with type 2 diabetes from diabetic nephropathy. We now characterized the interaction of thiol-containing compounds with CN1 cysteine residue at position 102, which is important for CN1 activity. Reduced glutathione (GSH), N-acetylcyst...