Assessing Drug-Induced Mitochondrial Toxicity in Cardiomyocytes: Implications for Preclinical Cardiac Safety Evaluation

• Hauptverfasser: Xiaoli Tang (Verfasst von), Zengwu Wang (Verfasst von), Shengshou Hu (Verfasst von), Bingying Zhou (Verfasst von)
• Format: Buch
• Veröffentlicht: MDPI AG, 2022-06-01T00:00:00Z.
• Schlagworte: article
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Drug-induced cardiotoxicity not only leads to the attrition of drugs during development, but also contributes to the high morbidity and mortality rates of cardiovascular diseases. Comprehensive testing for proarrhythmic risks of drugs has been applied in preclinical cardiac safety assessment for ove...