Device-Controlled Microcondensation for Spatially Confined On-Tissue Digests in MALDI Imaging of <i>N</i>-Glycans

• Main Authors: Annabelle Fülöp (Author), Christian Marsching (Author), Frederik Barka (Author), Yasemin Ucal (Author), Pauline Pfänder (Author), Christiane A. Opitz (Author), Günes Barka (Author), Carsten Hopf (Author)
• Format: Book
• Published: MDPI AG, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

On-tissue enzymatic digestion is a prerequisite for MALDI mass spectrometry imaging (MSI) and spatialomic analysis of tissue proteins and their <i>N</i>-glycan conjugates. Despite the more widely accepted importance of <i>N</i>-glycans as diagnostic and prognostic biomarkers...