Ambra1 deficiency impairs mitophagy in skeletal muscle

• Main Authors: Lisa Gambarotto (Author), Samuele Metti (Author), Martina Chrisam (Author), Cristina Cerqua (Author), Patrizia Sabatelli (Author), Andrea Armani (Author), Carlo Zanon (Author), Marianna Spizzotin (Author), Silvia Castagnaro (Author), Flavie Strappazzon (Author), Paolo Grumati (Author), Matilde Cescon (Author), Paola Braghetta (Author), Eva Trevisson (Author), Francesco Cecconi (Author), Paolo Bonaldo (Author)
• Format: Book
• Published: Wiley, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Maintaining healthy mitochondria is mandatory for muscle viability and function. An essential surveillance mechanism targeting defective and harmful mitochondria to degradation is the selective form of autophagy called mitophagy. Ambra1 is a multifaceted protein with well‐known a...