"Small is beautiful" - Examining reliable determination of low-abundant therapeutic antibody glycovariants

• Main Authors: Katharina Böttinger (Author), Christof Regl (Author), Veronika Schäpertöns (Author), Erdmann Rapp (Author), Therese Wohlschlager (Author), Christian G. Huber (Author)
• Format: Book
• Published: Elsevier, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Glycans associated with biopharmaceutical drugs play crucial roles in drug safety and efficacy, and therefore, their reliable detection and quantification is essential. Our study introduces a multi-level quantification approach for glycosylation analysis in monoclonal antibodies (mAbs), focusing on...